Lack of association of the (AAAT)6 allele of the GXAlu tetranucleotide repeat in intron 27b of the NF1 gene with autism.

Autor: Plank SM; Presbyterian College, Clinton, South Carolina, USA., Copeland-Yates SA, Sossey-Alaoui K, Bell JM, Schroer RJ, Skinner C, Michaelis RC
Jazyk: angličtina
Zdroj: American journal of medical genetics [Am J Med Genet] 2001 Jul 08; Vol. 105 (5), pp. 404-5.
DOI: 10.1002/ajmg.1432
Abstrakt: A novel allele of the GXAlu tetranucleotide repeat in intron 27b of the neurofibromatosis 1 (NF1) gene has recently been reported to be present in 4.7% of autistic patients but not in controls. We have found the novel GXAlu allele absent in 204 patients from the South Carolina Autism Project and 200 controls. The autism population studied includes a significant number of patients with hypotonia, stereotyped behaviors, or postural, gait, and motor abnormalities similar to those seen in the patients previously reported to possess the novel GXAlu allele. This suggests that the novel (AAAT)6 GXAlu allele is not associated with autism.
(Copyright 2001 Wiley-Liss, Inc.)
Databáze: MEDLINE
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