Membrane traffic: how do GGAs fit in with the adaptors?

Autor: Black MW; MRC-Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, UK., Pelham HR
Jazyk: angličtina
Zdroj: Current biology : CB [Curr Biol] 2001 Jun 26; Vol. 11 (12), pp. R460-2.
DOI: 10.1016/s0960-9822(01)00281-0
Abstrakt: The AP-1 adaptor complex has been cast as the major player in clathrin coat formation for vesicular transport from the trans-Golgi to the endocytic pathway. But new results on 'GGA' proteins have raised doubts about this paradigm and suggest both a new sorting mechanism and an unexpected complexity in the roles of clathrin.
Databáze: MEDLINE