| Autor: |
Box HC; Department of Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA. harold.box@roswellpark.org., Budzinski EE, Dawidzik J, Patrzyc HB, Freund HG |
| Jazyk: |
angličtina |
| Zdroj: |
Radiation research [Radiat Res] 2001 Aug; Vol. 156 (2), pp. 215-9. |
| DOI: |
10.1667/0033-7587(2001)156[0215:andlix]2.0.co;2 |
| Abstrakt: |
A single free radical-initiating event can produce a pair of base lesions in DNA oligomers exposed to ionizing radiation. Whereas double base lesions have been observed previously, the present study shows that double lesions may sometimes consist of a base lesion and an associated strand break. The mechanism for the formation of double lesions is discussed. A redox process is postulated in which guanine is the source of the electron. It is suggested that double lesions may be formed in DNA either on adjacent nucleotides or, alternatively, on nucleotides separated by one, two or possibly more intervening nucleotides. It is hypothesized that intramolecular electron transfer facilitates the formation of double lesions on nonadjacent nucleotides. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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