Fluoroquinolone resistance is a poor surrogate marker for type II topoisomerase mutations in clinical isolates of Streptococcus pneumoniae.

Autor: Millichap JJ; Departments of Pathology and Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA., Pestova E, Siddiqui F, Noskin GA, Peterson LR
Jazyk: angličtina
Zdroj: Journal of clinical microbiology [J Clin Microbiol] 2001 Jul; Vol. 39 (7), pp. 2719-21.
DOI: 10.1128/JCM.39.7.2719-2721.2001
Abstrakt: The association between fluoroquinolone susceptibility and DNA mutations coding for amino acid substitutions in the quinolone resistance-determining region was assessed with 44 clinical isolates of Streptococcus pneumoniae. Twenty-three strains bore at least one amino acid substitution. Only seven strains with mutations were suggested by diminished susceptibility to ciprofloxacin (MIC, > or =2 microg/ml).
Databáze: MEDLINE