Gender and age modify the association between APOE and AD-related neuropathology.

Autor:	Ghebremedhin E; Department of Clinical Neuroanatomy, J.W. Goethe-University, Frankfurt, Germany. Ghebremedhin@em.uni-frankfurt.de, Schultz C, Thal DR, Rüb U, Ohm TG, Braak E, Braak H
Jazyk:	angličtina
Zdroj:	Neurology [Neurology] 2001 Jun 26; Vol. 56 (12), pp. 1696-701.
DOI:	10.1212/wnl.56.12.1696
Abstrakt:	Objective: To assess the impact of apolipoprotein E (APOE) polymorphism on AD-related neurofibrillary tangle (NFT) formation and senile plaques (SP). Methods: A sample of 729 routine autopsy brains (359 men, 370 women; age range, 60 to 99 years) was investigated. All brains were classified neuropathologically according to a procedure permitting differentiation of six NFT stages and three SP stages. APOE genotyping was performed on all cases. Results: The epsilon4 allele of APOE was associated not only with SP (p < 0.0001) but also with NFT formation (p < 0.0001). The effect of the epsilon4 allele on NFT formation was noted at ages > or =80 years (p < 0.0001) but not between ages 60 and 79 years (p = 0.12). An association between the epsilon4 allele and SP for women was found at ages 60 to 79 years (p < 0.0001) but not at > or =80 years of age (p = 0.063). By comparison, men showed an association in both age categories (p = 0.001 and p = 0.001). Conclusion: The results confirm the association between the epsilon4 allele and both types of AD-related lesions and show that this association is differentially modified by age and gender.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu