[Changes in biochemical inflammation markers in evaluation of the effectiveness of basic chemotherapy in bronchial asthma].

Autor:	Nevzorova VA, Prosekova EV, Gel'tser BI, Luk'ianov PA, Shestovskaia TN, Maĭstrovskaia IuV, Arzamastseva AI
Jazyk:	ruština
Zdroj:	Terapevticheskii arkhiv [Ter Arkh] 2001; Vol. 73 (3), pp. 24-7.
Abstrakt:	Aim: To analyse informative value of monitoring of NO metabolites concentration in condensate of expired air vapor (EAVC) for definition of bronchial asthma (BA) severity and antiinflammatory effect of basic therapy. Material and Methods: NO metabolites concentration in EAVC was measured with Grace's reagent in 76 adults and 180 children in the course of basic therapy with flixotide, tailed, ketotiphen with intal. Results: NO metabolites occurred in high concentrations in EAVC of both children and adults. These concentrations were the highest in attacks and in severe BA and were reduced by basic therapy. This effect differed with the drug and its dose, e.g. flixotide and tailed given to children for a month reduced NO metabolites close to concentrations observed in healthy subjects. Ketotiphen and intal for 6 months failed to low NO metabolites significantly. Conclusion: NO secretion monitoring is sensitive in assessment of respiratory inflammation in BA and is informative in assessment of effectiveness of the basic therapy. In moderate BA children on flixotide and tailed were the first to achieve normal NO secretion in the airways.
Databáze:	MEDLINE
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