Myofibroblasts in the accessory ligament (distal check ligament) and the deep digital flexor tendon of foals.
| Autor: | Hartzel DK; Laboratory for Comparative Orthopaedic Research, College of Veterinary Medicine, Michigan State University, East Lansing 48824, USA., Arnoczky SP, Kilfoyle SJ, Stick JA |
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| Jazyk: | angličtina |
| Zdroj: | American journal of veterinary research [Am J Vet Res] 2001 Jun; Vol. 62 (6), pp. 823-7. |
| DOI: | 10.2460/ajvr.2001.62.823 |
| Abstrakt: | Objective: To demonstrate myofibroblasts in the accessory ligament of the deep digital flexor tendon (ie, distal check ligament) and deep digital flexor tendon of clinically normal foals. Sample Population: Tissue specimens from 25 foals that were necropsied for reasons unrelated to this study and unrelated to musculoskeletal disease. Procedure: The distal check ligament and deep digital flexor tendon of both forelimbs were examined histologically. Myofibroblasts were identified by immunohistochemical staining specific for alpha-smooth muscle actin (alpha-SMA). Results: Most of the cells in the distal check ligament and deep digital flexor tendon of all foals stained positive for alpha-SMA. Conclusion and Clinical Relevance: Myofibroblasts made up most of the cells in the distal check ligament and deep digital flexor tendon of clinically normal foals. These cells have contractile ability and therefore, may play a role in flexure contracture of these tendons. The ability of tetracycline to chelate calcium or decrease the expression of the contractile protein alpha-smooth muscle actin could inhibit the myofibroblasts' ability to contract, thus providing a rationale for tetracycline administration as a treatment of distal interphalangeal joint flexor deformity in foals. |
| Databáze: | MEDLINE |
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