| Autor: |
Gunnewijk MG; Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, The Netherlands., van den Bogaard PT, Veenhoff LM, Heuberger EH, de Vos WM, Kleerebezem M, Kuipers OP, Poolman B |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of molecular microbiology and biotechnology [J Mol Microbiol Biotechnol] 2001 Jul; Vol. 3 (3), pp. 401-13. |
| Abstrakt: |
The involvement of phosphoeno/pyruvate:sugar phosphotransferase (PTS) proteins, like HPr and IIA(Glc), in the regulation of carbohydrate utilization has been well established in Gram-negative and Gram-positive bacteria. The majority of the studies of PTS-mediated regulation have been concerned with the hierarchical control of carbohydrate utilization, which results in the preferential utilization of a particular carbohydrate from a mixture of substrates. The underlying mechanisms of PTS-mediated hierarchical control involve the inhibition of expression of other catabolic enzymes and transporters and/or the allosteric regulation of their activity, which prevents the transcriptional inducer to be formed or taken up into the cell. More recently, it has become clear that PTS components allow also the cell to tune the uptake rate(s) to the carbohydrate availability in the medium and the metabolic capacity of the cell. The different phosphorylated species of HPr play a central role in this autoregulatory control circuit, both at the gene and at the protein level. Our knowledge of hierarchical control and autoregulation of carbohydrate utilization in bacteria is discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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