| Autor: |
Thomas J, Berkoff CE, Flagg WB, Gallo JJ, Haff RF, Pinto CA |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of medicinal chemistry [J Med Chem] 1975 Mar; Vol. 18 (3), pp. 245-50. |
| DOI: |
10.1021/jm00237a005 |
| Abstrakt: |
Eighty-four 4-quinolinehydrazones were synthesized and tested for antiviral activity. Thirty nine derivatives were active against influenza A2 and/or Coxsackie B1 in mice at a dose of 25 mg/kg sc. Structure-activity relationships of 44 derivatives (21 inactive) were analyzed qualitatively using a modified Free-Wilson approach. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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