[Importance of the bacterium-host interaction in coagulase-negative staphylococci isolated from neonates].

Autor:	Bogado IE; Departamento de Microbiología, Cátedra Microbiología Clínica I, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, República, Argentina. ibogado@arnet.com.ar, Marchiaro P, Marzi M, Putero J, Ivancovich JJ, Sutich EG
Jazyk:	Spanish; Castilian
Zdroj:	Enfermedades infecciosas y microbiologia clinica [Enferm Infecc Microbiol Clin] 2001 Apr; Vol. 19 (4), pp. 165-71.
Abstrakt:	Objective: Neonates represent a high risk population for infections by coagulase-negative staphylococci (CNS). To have a better understanding of these process our purpose was to compare the expected result of the bacterium-host interaction given by the neonates' risks factors and the micro-organisms' virulence factors with the condition of infecting or colonising strain that emerge from the diagnosis on the basis of the clinical symptoms. Methods: We studied 24 neonates who were submitted to an epidemiological control establishing as risk factors: catheters, vesicle sounds, previous surgery and immunodepressed conditions. In the CNS recovered from clinical samples we determined the following virulence factors: synergistic hemolysis, slime production, adherence to Teflon catheters and hydrophobicity. Results: We found correlation between the clinical diagnosis and the expected result of the bacterium-host interaction in 21 patients (87.5%). Among them, in 8 patients infection didn't occurred in spite of having the micro-organisms 3 from 4 virulence factors since the patients didn't have risk factors. Conclusions: A microbiological study based entirely on identification and treatment can alter the biological context. It is necessary to understand the bacterium-host interaction for an appropriate comprehension of the bacterial diseases.
Databáze:	MEDLINE
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