Functional evaluation of HIV/SIV Nef as superantigen.
| Autor: | Lapatschek MS; Institute of Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, Trogerstrasse 9, Munich, 81675, Germany., Dürr S, Sutter G, Wagner H, Miethke T |
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| Jazyk: | angličtina |
| Zdroj: | Virology [Virology] 2001 Apr 10; Vol. 282 (2), pp. 329-37. |
| DOI: | 10.1006/viro.2001.0844 |
| Abstrakt: | It is speculated that a virus-encoded superantigen is involved in the pathogenesis of human and simian immunodeficiency virus infections and that the accessory protein Nef might be that superantigen. We are able to show, using a murine superantigen screening system, that Nef does not display features characteristic of a superantigen. Upon transfection into MHC class II expressing antigen-presenting cells, it is expressed, but fails to induce Vbeta-specific expansion of peripheral T lymphocytes, which is a characteristic feature of superantigens in mixed lymphocyte culture. Therefore, we cannot support the hypothesis that Nef is a superantigen. The observations in favor of that hypothesis must be explained by other mechanisms. (Copyright 2001 Academic Press.) |
| Databáze: | MEDLINE |
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