| Autor: |
Zawalich WS; Yale University School of Nursing, New Haven, Connecticut 06536, USA. Walter.Zawalich@Yale.Edu, Zawalich KC, Tesz GJ, Sterpka JA, Philbrick WM |
| Jazyk: |
angličtina |
| Zdroj: |
American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2001 May; Vol. 280 (5), pp. E720-8. |
| DOI: |
10.1152/ajpendo.2001.280.5.E720 |
| Abstrakt: |
Islet responses of two different Mus geni, the laboratory mouse (Mus musculus) and a phylogenetically more ancient species (Mus caroli), were measured and compared with the responses of islets from rats (Rattus norvegicus). A minimal and flat second-phase response to 20 mM glucose was evoked from M. musculus islets, whereas a large rising second-phase response characterized rat islets. M. caroli responses were intermediate between these two extremes; a modest rising second-phase response to 20 mM glucose was observed. Prior, brief stimulation of rat islets with 20 mM glucose results in an amplified insulin secretory response to a subsequent 20 mM glucose challenge. No such potentiation or priming was observed from M. musculus islets. In contrast, M. caroli islets displayed a modest twofold potentiated first-phase response upon subsequent restimulation with 20 mM glucose. Inositol phosphate (IP) accumulation in response to 20 mM glucose stimulation in [(3)H]inositol-prelabeled rat or mouse islets paralleled the insulin secretory responses. The divergence in 20 mM glucose-induced insulin release between these species may be attributable to differences in phospholipase C-mediated IP accumulation in islets. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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