Cyclosporin, nifedipine and gingival hyperplasia: a randomized controlled study.

Autor: Morgan JD; Department of Surgery, Leicester General Hospital, UK., Swarbrick MJ, Edwards CM, Donnelly PK
Jazyk: angličtina
Zdroj: Transplant international : official journal of the European Society for Organ Transplantation [Transpl Int] 1994; Vol. 7 Suppl 1, pp. S320-1.
DOI: 10.1111/j.1432-2277.1994.tb01380.x
Abstrakt: Nifedipine increases the frequency and severity of gingival hyperplasia associated with CyA therapy in renal transplant recipients and this effect appears to be independent of whole-blood CyA levels. De novo malignancies have been reported arising in areas of gingival hyperplasia, in a group already at high risk of malignancy. Patients receiving CyA and nifedipine should receive advice regarding the need for strict oral hygiene to control the initial development of gingival hyperplasia, with severe cases being promptly referred for gingivectomy and histological examination.
Databáze: MEDLINE