| Autor: |
Patrzyc HB; Department of Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Carlton and Elm Streets, Buffalo, NY 14263, USA., Dawidzik JB, Budzinski EE, Iijima H, Box HC |
| Jazyk: |
angličtina |
| Zdroj: |
Radiation research [Radiat Res] 2001 Apr; Vol. 155 (4), pp. 634-6. |
| DOI: |
10.1667/0033-7587(2001)155[0634:dlapid]2.0.co;2 |
| Abstrakt: |
It was demonstrated previously that double lesions are produced in DNA by ionizing radiation. These double lesions consist of adjacent nucleotides each bearing a modified base. The goal of the present investigation was to determine whether Fenton chemistry can generate the same kind of lesions. DNA oligomers were exposed to metal-catalyzed H(2)O(2) reactions, and the products were characterized by chromatography and by mass spectrometry. Double lesions are produced by this treatment in which deoxyguanosine is oxidized to 8-oxo-7,8-dihydrodeoxyguanosine and an adjacent pyrimidine nucleoside is degraded to a formamido remnant. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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