| Autor: |
Cui CL; Neuroscience Research Center, Beijing Medical University, Beijing 100083., Wu LZ, Han JS |
| Jazyk: |
čínština |
| Zdroj: |
Yao xue xue bao = Acta pharmaceutica Sinica [Yao Xue Xue Bao] 1997; Vol. 32 (2), pp. 85-9. |
| Abstrakt: |
Intrathecal(i.t.) injection of 10 microliters of dynorphin A(1-17) 20 nmol.L-1 per rat resulted in irreversible hind limb paralysis and suppression of the tail-flick reflex lasting for up to 40 h. The dual effects of dynorphin appeared 5-10 min after the i.t. administration. Histologic examination of the spinal cord in the rats demonstrated dead and/or dying and degenerated motor-neurons in the ventral horn located predominately in the lumbar segment(a 87.2% reduction of the number of motor neurons, P < 0.01) and also in a lesser degree in sacral segment(-69.6%, P < 0.05). The thoracic segment was essentially normal(-8.2%, P > 0.05). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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