Refractive changes caused by hypoxia after laser in situ keratomileusis surgery.
| Autor: | Nelson ML; Ophthalmology Service, Madigan Army Medical Center, Tacoma, Washington 98431-5000, USA., Brady S, Mader TH, White LJ, Parmley VC, Winkle RK |
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| Jazyk: | angličtina |
| Zdroj: | Ophthalmology [Ophthalmology] 2001 Mar; Vol. 108 (3), pp. 542-4. |
| DOI: | 10.1016/s0161-6420(00)00592-3 |
| Abstrakt: | Objective: To determine whether hypoxia induces refractive changes in subjects who have had laser in situ keratomileusis (LASIK) refractive surgery. Design: Prospective paired eye clinical trial. Participants: There were 20 LASIK subjects (40 eyes) and 20 myopic non-LASIK controls (40 eyes). Intervention: Each subject had one eye exposed to ocular surface hypoxia (humidified nitrogen) by use of an airtight goggle system at sea level for 2 hours. The other eye was simultaneously exposed to humidified, compressed air (21% oxygen) with the same airtight goggle system. Main Outcome Measures: Keratometry, cycloplegic refraction, and pachymetry were compared before and after exposure by use of repeated measures analysis of variance. Results: A significant myopic shift (P: < 0.01) occurred in LASIK corneas exposed to hypoxia compared with myopic control subjects. A significant increase in corneal thickening occurred symmetrically in both LASIK and control subjects exposed to hypoxia. There was a trend toward corneal steepening (keratometry) in LASIK subjects, but this was not statistically significant. Conclusions: These results suggest that ocular surface hypoxia induces a myopic shift in LASIK subjects. |
| Databáze: | MEDLINE |
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