[In vitro comparative activity of moxifloxacin and other antimicrobials against respiratory pathogens].
| Autor: | Prado V; Unidad de Microbiología, Oriente, Programa de Microbiología y Micrología, ICBM, Facultad de Medicina, Universidad de Chile. vprado@machi.med.uchile.cl, Giangrieco M, Durán C, Ojeda A, van Flaskamp R |
|---|---|
| Jazyk: | Spanish; Castilian |
| Zdroj: | Revista medica de Chile [Rev Med Chil] 2000 Dec; Vol. 128 (12), pp. 1319-26. |
| Abstrakt: | Background: Respiratory pathogens are becoming increasingly resistant to antimicrobials. A new group of drugs, called respiratory quinolones have been synthesized to overcome this problem. Aim: To study the in vitro susceptibility of respiratory pathogens to old and new antimicrobials. Materials and Methods: Forty five strains of S pneumoniae, 44 strains of H influenzae, 21 strains of M catarrhalis, 10 strains of methicillin susceptible S aureus and 20 strains of methicillin resistant S aureus were studied. All were isolated from community acquired respiratory infections during 1999. Minimal inhibitory concentrations of moxifloxacin, amoxicillin, amoxicillin/clavulanic acid, clarithromycin, azithromycin, ciprofloxacin and levofloxacin were determined using the Etest method. Beta-lactamase production by H influenzae and M catarrhalis was also studied. Results: S pneumoniae strains were 100% susceptible to quinolones and cotrimoxazole, 2% were resistant to macrolides, 11% were resistant to amoxicillin/clavulanic acid and 47% were resistant to cefuroxime. H influenzae was 100% susceptible to quinolones, azithromycin and amoxicillin/clavulanic acid. There was a 53% resistance to cotrimoxazole, 21% to amoxicillin, 9% to clarithromycin and 7% to cefuroxime. M catarrahalis was 100% susceptible to quinolones and 100% resistant to amoxicillin, 5% resistant to macrolides, 14% resistant to amoxicillin/clavulanic acid, 20% to cefuroxime and 30% to cotrimoxazole. Methicillin susceptible S aureus was susceptible to all antimicrobials and methicillin resistant S aureus was resistant to all. Conclusions: Maxifloxacin and the new respiratory quinolones can be useful in the treatment of respiratory infections. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|