| Autor: |
Wolen RL, Ziege EA, Gruber CM Jr |
| Jazyk: |
angličtina |
| Zdroj: |
Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 1975 Jan; Vol. 17 (1), pp. 15-20. |
| DOI: |
10.1002/cpt197517115 |
| Abstrakt: |
The kinetics of propoxyphene and its primary metabolite, norpropoxyphene, have been simultaneously re-evaluated in man by using gas-liquid chromatography/mass spectrometry, deuterium-labeled mass internal standards, and multiple ion monitoring. Plasma concentrations in 4 volunteers determined for as long as 240 hr after single oral doses of 2 propoxyphene salts indicate the overall half-life of propoxyphene to be 11.8 hr and of norpropoxyphene to be 36.6 hr. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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