[Morpho-functional condition of heart in patients with lymphogranulomatosis late after chemoradiotherapy].

Autor:	Loseva MP, Purtova LA, Gavalova RF, Pospelova TI, Soldatova GS
Jazyk:	ruština
Zdroj:	Terapevticheskii arkhiv [Ter Arkh] 2000; Vol. 72 (10), pp. 64-7.
Abstrakt:	Aim: The study of clinical and echocardiographic status of the heart in patients with lymphogranulomatosis (LGM) late after chemoradiotherapy. Material and Methods: 44 patients with IIA-IV stage of LGM exposed to irradiation of lymph nodes and polychemotherapy according to the schemes ACOP, ABVD, COPP, CHOP, CVPP were examined. Echocardiography was carried out on the unit Sigma-44 and Toshiba. Results: Some changes in the heart by type of myocardiodystrophy or endomyocardial fibrosis were found. The latter are characterized by diminution of the left and (or) right ventricles due to apex obliteration, hardening and thickening of the endocardium and subvalvular structures, diastolic dysfunction and pulmonary hypertension. The main and additional signs are distinguished. The reasons of endomyocardial fibrosis are discussed: severity of the disease, frequent exacerbations and, consequently, higher doses of specific chemoradiotherapy. Conclusion: It is necessary to employ sparing policy in planning radiotherapy after high loading antracycline antibiotics.
Databáze:	MEDLINE
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