Expression of p53 and lactate dehydrogenase in murine fibrosarcoma following exposure to gamma-radiation.

Autor: Wani K; Radiation Oncology Division, Nanavathi Hospital and Medical Research Centre, Mumbai, India., Rajagopalan R, Huilgol NG, Nair CK
Jazyk: angličtina
Zdroj: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer [J Environ Pathol Toxicol Oncol] 2001; Vol. 20 (1), pp. 33-7.
Abstrakt: Radiation-induced alterations in the levels of p53 and lactate dehydrogenase activities were studied in fibrosarcoma, following exposure to different doses of gamma-irradiation (2-10 Gy). The levels of p53 were elevated in the cytoplasm, while the lactate dehydrogenase activity in tumor tissue was considerably decreased.
Databáze: MEDLINE