| Autor: |
Pérez De Nanclares G; Endocrinology and Diabetes Research Group, Hospital de Cruces, Barakaldo-Basque Country, Spain., Bilbao JR, Calvo B, Castaño L |
| Jazyk: |
angličtina |
| Zdroj: |
Autoimmunity [Autoimmunity] 2000; Vol. 33 (1), pp. 33-6. |
| DOI: |
10.3109/08916930108994107 |
| Abstrakt: |
Over the last few years several studies of linkage between non-HLA loci and type 1 diabetes mellitus have mapped several putative susceptibility genes on chromosome 6q; in fact, positive evidence of linkage and/or association of IDDM5 (6q25), IDDM8 (6q27) and IDDM15 (6q21) with type 1 diabetes has been reported. We have studied these loci in diabetic families of Basque origin, a genetically homogeneous population, to avoid artifactual association results due to admixture within the sample analysed. Statistical analyses of linkage were performed using a transmission disequilibrium test (TDT). We could not confirm linkage for IDDM5, IDDM8 and IDDM15 in our population, possibly due to population-specific differences in genetic susceptibility and/or environmental triggering factors to type 1 diabetes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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