| Autor: |
O'Neill MF; Lilly Research Centre, Eli Lilly & Co, Surrey, UK. oneill_michael_f@lilly.com, Conway MW |
| Jazyk: |
angličtina |
| Zdroj: |
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2001 Apr; Vol. 24 (4), pp. 391-8. |
| DOI: |
10.1016/S0893-133X(00)00196-2 |
| Abstrakt: |
The purpose of this study was to further examine the effect of activation of 5-HT(1A) and 5-HT(1B) receptors in the forced swim test in mice and to determine if activation of these receptors played a role in the mediation of the effects of the tricyclic antidepressant imipramine. The 5-HT(1A) agonist 8-OH-DPAT decreased immobility in the forced swim test in mice as previously described. Both the selective 5-HT(1B) agonist anpirtoline (1.25-5 mg/kg) and mixed 5-HT(1A/B) agonist RU24969 (0.6-2.5 mg/kg) significantly increased time spent swimming in the FST. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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