| Autor: |
Gradden CW; Regional Renal Unit, Royal Liverpool Hospital, Liverpool, UK. farndon@freeuk.com, Pai P, Hindell P, O'Donoghue DJ, Mason H, Bell GM |
| Jazyk: |
angličtina |
| Zdroj: |
QJM : monthly journal of the Association of Physicians [QJM] 2001 Feb; Vol. 94 (2), pp. 79-87. |
| DOI: |
10.1093/qjmed/94.2.79 |
| Abstrakt: |
Modulation of biotransformation by genetic traits may be important in determining environmentally-induced nephrotoxicity. We conducted a case-control study to investigate the role of occupational hydrocarbon exposure, along with polymorphisms of the genes coding for N-acetyltransferase 2 (NAT2) and glutathione S-transferase mu (GSTmu), in the development of idiopathic membranous glomerulonephritis (IMGN). Patients (n=36) with biopsy-proven IMGN were matched with healthy controls for age, gender, and geographical area. Lifetime hydrocarbon exposure was assessed by a validated questionnaire. The polymorphisms of the NAT2 and GSTmu genes (GSTM1) were defined by use of a polymerase chain reaction on white-cell DNA from peripheral blood. Exposure to hydrocarbons was significantly greater in patients with IMGN than in controls (mean+/-SEM hydrocarbon exposure score 11 003+/-2955.7 vs. 4352+/-1418, p<0.02). NAT2 acetylator status was identical in patients and controls with 23 (63.9%) fast and 13 (36.1%) slow acetylators in each group. GSTmu was present in 15 (41.7%) patients and 16 (44.4%) controls. While occupational exposure to hydrocarbons remains a likely factor in its pathogenesis, further work is required to identify the genetic polymorphisms that modulate the risk of IMGN. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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