A brief history of testosterone.
| Autor: | Freeman ER; Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA., Bloom DA, McGuire EJ |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of urology [J Urol] 2001 Feb; Vol. 165 (2), pp. 371-3. |
| DOI: | 10.1097/00005392-200102000-00004 |
| Abstrakt: | Purpose: We explore the history of testosterone in the context of medical and scientific developments. Materials and Methods: A review of the scientific and historical literature was conducted. Results: The origins and effects of testosterone have been recognized throughout the history of humankind. Hunter performed testicular transplantation experiments in 1767 while studying tissue transplantation techniques, and almost a century later Berthold linked the physiological and behavioral changes of castration to a substance secreted by the testes. Brown-Séquard gave birth to the field of organotherapy in 1889 when he announced that his auto-injection of testicular extracts resulted in rejuvenated physical and mental abilities. Steinach and Niehans expanded upon Brown-Séquard's work with rejuvenation treatments involving vasoligation, tissue grafts and cellular injections. In 1935 David et al isolated the critical ingredient in organotherapeutic treatments, testosterone. Conclusions: The effects of the powerful hormone testosterone continue to inspire research and controversy 65 years later. |
| Databáze: | MEDLINE |
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