Inhibition of hBD-3, but not hBD-1 and hBD-2, mRNA expression by corticosteroids.
| Autor: | Duits LA; Department of Infectious Diseases, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands., Rademaker M, Ravensbergen B, van Sterkenburg MA, van Strijen E, Hiemstra PS, Nibbering PH |
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| Jazyk: | angličtina |
| Zdroj: | Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2001 Jan 19; Vol. 280 (2), pp. 522-5. |
| DOI: | 10.1006/bbrc.2000.4157 |
| Abstrakt: | Intensive use of corticosteroids may be accompanied by increased susceptibility to infections; hence, we investigated the effects of dexamethasone on the expression of antimicrobial peptides, termed human beta-defensins (hBD), by cultured bronchial epithelial cells and mononuclear phagocytes. The results revealed that dexamethasone inhibited the (stimulated) expression of mRNA for hBD-3, but not hBD-1 and hBD-2 by these epithelial cells. Dexamethasone did not affect the (stimulated) mRNA expression of hBD-1 and hBD-2 by mononuclear phagocytes, whereas these cells did not express hBD-3 mRNA. (Copyright 2001 Academic Press.) |
| Databáze: | MEDLINE |
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