| Autor: |
El-Mallakh RS; Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Louisville, KY 40292, USA., Huff MO |
| Jazyk: |
angličtina |
| Zdroj: |
Harvard review of psychiatry [Harv Rev Psychiatry] 2001 Jan-Feb; Vol. 9 (1), pp. 23-32. |
| DOI: |
10.1080/10673220127873 |
| Abstrakt: |
Understanding the pathogenesis and pathophysiology of bipolar disorder is a prerequisite for accelerating the development of effective therapeutic agents and interventions. One of the best clues to these processes lies in shared mechanisms of action of mood-stabilizing agents. All effective mood stabilizers share the ability to attenuate the influx and intracellular accumulation of sodium in an activity-dependent manner. When coupled with independent observations of aberrant ion regulation in mania and bipolar depression, this shared characteristic is potentially significant. A unified hypothesis is presented in which lithium, valproic acid, and carbamazepine are suggested to produce antimanic effects by modifying ion flux and intracellular ion concentrations. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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