| Autor: |
Caserta F; Obesity Research Center, Evans Department of Medicine, Boston University Medical Center, Boston, Massachusetts 02118, USA., Tchkonia T, Civelek VN, Prentki M, Brown NF, McGarry JD, Forse RA, Corkey BE, Hamilton JA, Kirkland JL |
| Jazyk: |
angličtina |
| Zdroj: |
American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2001 Feb; Vol. 280 (2), pp. E238-47. |
| DOI: |
10.1152/ajpendo.2001.280.2.E238 |
| Abstrakt: |
Regional differences in free fatty acid (FFA) handling contribute to diseases associated with particular fat distributions. As cultured rat preadipocytes became differentiated, FFA transfer into preadipocytes increased and was more rapid in single perirenal than in epididymal cells matched for lipid content. Uptake by human omental preadipocytes was greater than uptake by abdominal subcutaneous preadipocytes. Adipose-specific fatty acid binding protein (aP2) and keratinocyte lipid binding protein abundance was higher in differentiated rat perirenal than in epididymal preadipocytes. This interdepot difference in preadipocyte aP2 expression was reflected in fat tissue in older animals. Carnitine palmitoyltransferase 1 activity increased during differentiation and was higher in perirenal than in epididymal preadipocytes, particularly the muscle isoform. Long-chain acyl-CoA levels were higher in perirenal than in epididymal preadipocytes and isolated fat cells. These data are consistent with interdepot differences in fatty acid flux ensuing from differences in fatty acid binding proteins and enzymes of fat metabolism. Heterogeneity among depots results, in part, from distinct intrinsic characteristics of adipose cells. Different depots are effectively separate miniorgans. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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