Effect of three caffeine doses on plasma catecholamines and alertness during prolonged wakefulness.

Autor: Kamimori GH; Department of Neurobiology and Behavior, Division of Neuropsychiatry, Walter Reed Army Institute of Research, Washington, DC 20307-5100, USA. gary.kamimori@na.amedd.army.mil, Penetar DM, Headley DB, Thorne DR, Otterstetter R, Belenky G
Jazyk: angličtina
Zdroj: European journal of clinical pharmacology [Eur J Clin Pharmacol] 2000 Nov; Vol. 56 (8), pp. 537-44.
DOI: 10.1007/s002280000186
Abstrakt: Objective: Determine the relationship between caffeine, catecholamines, and alertness during prolonged wakefulness.
Methods: Following 49 h of prolonged wakefulness, each of 50 healthy males (18-32 years) orally ingested either a placebo or one of three doses of caffeine, 2.1 (low), 4.3 (medium), or 8.6 mg kg-1 body weight (high), in a randomized double-blind design. Wakefulness continued for an additional 12 h during which venous blood samples were collected for catecholamine and caffeine analysis [determined using high-performance liquid chromatography (HPLC)]. A sleep latency test, the Stanford sleepiness scale, and a choice reaction time test were administered periodically during the post-dosing period and served as measures of alertness (physiological, subjective, and behavioral, respectively).
Results: Caffeine had no significant effect on noradrenaline, but adrenaline was significantly increased between 1 h and 4 h post-dosing in the high dose group compared with a placebo group. Following caffeine administration, responses to sleep latency, sleepiness scores, and reaction time scores showed dose-related changes that were exhibited by significant correlation coefficients.
Conclusion: The results indicate that high doses of caffeine have a significant and beneficial effect on alertness during prolonged wakefulness.
Databáze: MEDLINE
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