| Autor: |
Cho SN; Department of Microbiology, Yonsei University College of Medicine, Seoul 120-752, The Republic of Korea. raycho@yumc.yonsei.ac.kr, Cellona RV, Villahermosa LG, Fajardo TT Jr, Balagon MV, Abalos RM, Tan EV, Walsh GP, Kim JD, Brennan PJ |
| Jazyk: |
angličtina |
| Zdroj: |
Clinical and diagnostic laboratory immunology [Clin Diagn Lab Immunol] 2001 Jan; Vol. 8 (1), pp. 138-42. |
| DOI: |
10.1128/CDLI.8.1.138-142.2001 |
| Abstrakt: |
A total of 100 untreated new leprosy patients were recruited prospectively and examined for the presence of phenolic glycolipid I (PGL-I) antigen in their serum specimens by dot enzyme-linked immunosorbent assay (ELISA) using rabbit anti-PGL-I antiserum. The presence of circulating PGL-I antigen was closely related to the bacterial indices (BI) of the patients. The PGL-I antigen was detectable in 27 (93.1%) of 29 patients with a BI of 4.0 or above and in 15 (68.2%) of 22 patients with a BI of 3.0 to 3.9. However, none of the 37 patients with a BI of less than 1.9 had detectable PGL-I antigen by the methods used in this study. The level of PGL-I in serum declined rapidly by about 90% 1 month after the start of multidrug therapy. This study showed clearly that anti-PGL-I IgM antibodies and circulating PGL-I antigen levels reflect the bacterial loads in untreated leprosy patients. The serological parameters based on the PGL-I antigen may therefore be useful in the assessment of leprosy patients at the time of diagnosis and possibly in monitoring patients following chemotherapy. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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