| Autor: |
de Kleijn ED; Department of Pediatrics, University Hospital Rotterdam/Sophia Children's Hospital, Dr Molewaterplein 60, 3015 GJ, Rotterdam, The Netherlands., de Groot R, Lafeber AB, Labadie J, van Limpt KC, Visser J, Berbers GA, van Alphen L, Rümke HC |
| Jazyk: |
angličtina |
| Zdroj: |
Vaccine [Vaccine] 2000 Dec 08; Vol. 19 (9-10), pp. 1141-8. |
| DOI: |
10.1016/s0264-410x(00)00320-0 |
| Abstrakt: |
The safety and immunogenicity of two PorA-based meningococcal outer membrane vesicle (OMV) vaccines against the P1.4 serosubtype adsorbed with AlPO(4) or Al(OH)(3) were studied in 134 toddlers. Vaccinations were given three times with an interval of 3-6 weeks or twice with an interval of 6-10 weeks. A vaccination was repeated after 20-40 weeks. Pre- and post-immunization sera were tested for bactericidal activity against an isogenic strain expressing P1.7(h), 4 PorA. Both meningococcal OMV vaccines were well tolerated. The percentage of children with a fourfold increase in bactericidal activity was 96% (AlPO(4)-adjuvated vaccine/2+1 schedule), 100% (AlPO(4)-adjuvated vaccine/3+1 schedule), 93% (Al(OH)(3)-adjuvated vaccine/2+1 schedule) and 97% (Al(OH)(3)-adjuvated vaccine/3+1 schedule). Adsorption with AlPO(4) makes the OMV vaccine more immunogenic than adsorption with Al(OH)(3). Bactericidal activity was highest after the 3+1 schedule, although the response shortly after the primary series was higher in the two-dose priming group. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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Full Text from ScienceDirect