| Autor: |
Kruger JM; Department of Small Animal Clinical Sciences, Michigan State University College of Veterinary Medicine, East Lansing 48824-1314, USA. kruger@cvm.msu.edu, Venta PJ, Swenson CL, Syring R, Gibbons-Burgener SN, Richter M, Maes RK |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of veterinary internal medicine [J Vet Intern Med] 2000 Nov-Dec; Vol. 14 (6), pp. 593-7. |
| DOI: |
10.1892/0891-6640(2000)014<0593:pobhii>2.3.co;2 |
| Abstrakt: |
The gammaherpesvirus bovine herpesvirus-4 (BHV-4) has been isolated from a wide variety of animals, including lions and domestic cats. Although BHV-4 antibodies have been detected in normal cats and cats with urinary disorders, the epidemiology and pathogenic role of BHV-4 in cats is unknown. The purpose of this study was to determine the prevalence of BHV-4 antibodies and viral nucleic acid in a population of free-roaming cats. Plasma and peripheral blood leukocyte samples were collected from 52 male and 52 female free-roaming cats impounded at a regional animal control facility in Central Michigan. Plasma concentrations of BHV-4 antibodies were measured with an indirect fluorescent antibody test. Peripheral blood leukocyte DNA was isolated, and a 2-stage polymerase chain reaction with heminested primers delineating a conserved portion of the BHV-4 glycoprotein B gene homologue was used to amplify BHV-4-specific DNA sequences. BHV-4 antibodies were detected in 38 (73%) male and 23 (44%) female cats. Seropositive cats were significantly more likely to be male than female (odds ratio = 3.22; P = .007). Cell-associated viremia was detected in 17 (33%) male and 11 (21%) female cats. Of the 61 seropositive cats, 23 (38%) had a detectable viremia; only 5 (12%) seronegative cats had detectable viremia. Seropositive cats were significantly more likely to be viremic than seronegative cats (OR = 4.30: P = .009). Our results suggest that BHV-4 infection may be more widespread in certain cat populations than previously reported. Furthermore, many cats seropositive for BHV-4 antibodies have a concurrent cell-associated viremia. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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