[Immunological aspects of early stage rheumatoid arthritis diagnosis].

Autor:	Timofeev VT, Shostak NA, Loginova TK, Muradiants AA, Shvyreva NM, Dunaeva IuV
Jazyk:	ruština
Zdroj:	Terapevticheskii arkhiv [Ter Arkh] 2000; Vol. 72 (5), pp. 19-21.
Abstrakt:	Aim: To study immune status of patients with rheumatoid arthritis (RA) to improve immunodiagnosis at early stage of the disease. Materials and Methods: Immunological examination covered 28 patients with rheumatoid arthritis (RA) aged 16 to 72 years. The duration of RA varied from 1.5 months to 1.5 years. Lymphocyte population and T-lymphocyte subpopulation were measured using monoclonal antibodies. Serum Ig were measured in Reafarm plates. Results: Patients with stage II articular function insufficiency (AFI) demonstrated a significant lowering of the absolute number of lymphocytes, natural killers, elevated concentration of IgA compared to patients with less severe AFI. Patients with systemic symptoms had significantly decreased percentage of T-lymphocytes vs patients with isolated articular syndrome. Natural killers' levels were elevated in all the patients in early RA. A significant rise in the percentage of B-lymphocytes and serum IgG concentrations were also seen. In T-lymphopenia, relative amount of T-helpers and T-suppressors was significantly elevated while the ratio T-helpers/T-suppressors was reduced. Conclusion: Changes found in the immune status allows diagnosis of early RA, characterize immune disorders, help to select adequate immunomodulating therapy supporting function of the suppressor cells.
Databáze:	MEDLINE
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