| Autor: |
Taneja KL; Boston Probes, Bedford, Massachusetts 01730, USA. ktaneja@bostonprobes.com, Chavez EA, Coull J, Lansdorp PM |
| Jazyk: |
angličtina |
| Zdroj: |
Genes, chromosomes & cancer [Genes Chromosomes Cancer] 2001 Jan; Vol. 30 (1), pp. 57-63. |
| DOI: |
10.1002/1098-2264(2000)9999:9999<::aid-gcc1054>3.0.co;2-m |
| Abstrakt: |
In previous studies, we showed that peptide nucleic acid (PNA) probes have significant advantages over conventional synthetic RNA or DNA probes in FISH procedures for detecting telomeric and trinucleotide repeat sequences. Here, we report that directly labeled PNA probes recognizing chromosome-specific repeat sequences are also powerful tools for detecting and enumerating specific chromosomes in interphase and metaphase cells. This is illustrated by multicolor FISH experiments with cells from normal individuals and patients with numerical sex chromosome aberrations. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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