| Autor: |
Brook WJ; Department of Biochemistry & Molecular Biology, University of Calgary, AB, Canada. brook@ucalgary.ca |
| Jazyk: |
angličtina |
| Zdroj: |
Biochemistry and cell biology = Biochimie et biologie cellulaire [Biochem Cell Biol] 2000; Vol. 78 (5), pp. 585-91. |
| DOI: |
10.1139/o00-072 |
| Abstrakt: |
Growth and cell fate in the anterior-posterior (A/P) axis of the developing wing of Drosophila melanogaster are controlled by a stripe of cells bisecting the axis called the A/P organizer. Hedgehog (Hh) signaling from posterior to anterior cells induces the organizer. Several Hh-responsive genes expressed by cells of the organizer mediate its patterning activity. The Hh-signaling pathway controls the post-translational modification of the transcription factor Cubitus-interruptus (Ci) and the resulting local activation of Ci is required for the correct location of the A/P organizer. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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