| Autor: |
Galebskaia LV; Pavlov Medical University, St. Petersburg, Russia., Denisenko AD, Simkina NB, Tarasova IuV, Tolochko SI |
| Jazyk: |
ruština |
| Zdroj: |
Biofizika [Biofizika] 2000 Sep-Oct; Vol. 45 (5), pp. 878-81. |
| Abstrakt: |
The influence of human and bovine serum albumin on the proton-mediated lysis of human, rabbit and sheep erythrocytes was studied. An essential acceleration of hemolysis (2-7-fold) by the action of albumin was observed only at pH values below 4.0, i.e. at values at which the transition of albumin to the E conformation occurs. It was shown in the experiments with fatty-acid-free albumin and the protein loaded by palmitate that the accelerating effect of albumin was due to the hemolytic action of fatty acids released from the protein. As a result of the proton potentiation of detergent-dependent hemolysis, fatty acids released from E-albumin become more potent hemolytic agents. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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