| Autor: |
Wong WM; Rheumatology Department, Southampton General Hospital, Southampton University Hospitals NHS Trust, UK. rayw@cwcom.net, Vakis SA, Ayre KR, Ellwood CN, Howell WM, Tutt AL, Cawley MI, Smith JL |
| Jazyk: |
angličtina |
| Zdroj: |
Scandinavian journal of rheumatology [Scand J Rheumatol] 2000; Vol. 29 (5), pp. 282-7. |
| DOI: |
10.1080/030097400447651 |
| Abstrakt: |
Rheumatoid arthritis (RA) T cells respond poorly to conventional mitogens. We have examined the proliferative and cytokine responses of T cells to a synthetic trispecific antibody (Tsab) directed against CD2, CD3, and CD28. In 11 subjects RA T cells proliferated more, and secreted significantly more IL-2, in response to Tsab than did control peripheral blood (PB) cells. Very high levels of IL-2 were produced by 2 patients with aggressive disease. Measurement of intracellular IL-2, IFN-gamma, IL-4, and IL-5 by flow cytometry showed a Th1 pattern of cytokine production in 13 RA and 9 control subjects. We conclude that RA T cells are not irreversibly inactivated, and that spatial arrangement of stimulating molecules may be important in eliciting maximal responses. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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