[Scintigraphy with 99mTc-MIBI in the diagnosis of axillary lymph node invasion of breast cancer].

Autor: Mulero F; Servicios de Medicina Nuclear y Ginecología y Obstetricia del Hospital Universitario Virgen de la Arrixaca. El Palmar. Murcia. mulerof@teleline.es, Nicolás F, Castellón MI, Claver MA, Abad L, Nuño de la Rosa JA
Jazyk: Spanish; Castilian
Zdroj: Revista espanola de medicina nuclear [Rev Esp Med Nucl] 2000 Oct; Vol. 19 (6), pp. 416-22.
DOI: 10.1016/s0212-6982(00)71903-3
Abstrakt: Unlabelled: The presence of affected locoregional lymph nodes should be considered as one of the most important prognostic factors of breast cancer. At present, the clinician is conditioned by an absolute lack of an efficient methodology to evaluate the possible invasion of the axillary lymph nodes, which if negative, would make it possible to avoid surgical excision. In this study, we will evaluate the use of the 99mTc-MIBI scintigraphy in the pre-surgical diagnosis of axillary lymph node invasion and will analyze the relationship between the 99mTc-MIBI uptake and the number of lymph nodes affected.
Material and Methods: 84 patients diagnosed of breast cancer were analyzed in this study. All of them underwent a 99mTc-MIBI scintigraphy, and the tumor/background ratio was determined semiquantitively for each image. The axillary lymph node invasion was determined following surgery.
Results: The sensitivity of the breast scintigraphy with 99mTc-MIBI for detection of lymph node invasion is 36% and the specificity is 100%. The positive predictive value is 100% and the negative one 48%. In the current study, we failed to detect correlation between the intensity of 99mTc-MIBI uptake in the primary tumor and the number of affected axillary lymph nodes.
Conclusion: 99mTc-MIBI breast scintigraphy can provide complementary information for the presurgical diagnosis of breast cancer axillary lymph node invasion. 99mTc-MIBI breast scintigraphy shows high specificity and a high predictive value.
Databáze: MEDLINE
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