| Autor: |
Fort DM; Shaman Pharmaceuticals Inc., South San Francisco, California 94080-4812, USA. dfort@pharmanex.com, Ubillas RP, Mendez CD, Jolad SD, Inman WD, Carney JR, Chen JL, Ianiro TT, Hasbun C, Bruening RC, Luo J, Reed MJ, Iwu M, Carlson TJ, King SR, Bierer DE, Cooper R |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of organic chemistry [J Org Chem] 2000 Oct 06; Vol. 65 (20), pp. 6534-9. |
| DOI: |
10.1021/jo000568q |
| Abstrakt: |
Two new compounds, pycnanthuquinone A (1) and pycnanthuquinone B (2), were isolated from leaves and stems of the African plant, Pycnanthus angolensis (Welw.) Warb (Myristicaceae), by bioassay-guided fractionation of an ethanolic extract using a diabetic mouse model. Pycnanthuquinones A and B are the first representatives of a novel terpenoid-type quinone skeleton, and both compounds possess significant antihyperglycemic activity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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