| Autor: |
Borba JM; Laboratório de Fisiologia da Nutrição Naide Teodósio, Departamento de Nutrição, Universidade Federal de Pernambuco, Recife, PE, Brazil., Araújo MS, Picanço-Diniz CW, Manhães-de-Castro R, Guedes RC |
| Jazyk: |
angličtina |
| Zdroj: |
Brain research bulletin [Brain Res Bull] 2000 Sep 15; Vol. 53 (2), pp. 193-201. |
| DOI: |
10.1016/s0361-9230(00)00334-8 |
| Abstrakt: |
We investigated the histochemical positivity to NADPH-diaphorase, which reveals nitric oxide synthase activity, in area 17 of rats malnourished early in life, both in the post-weaning period (group M1), and in adulthood after nutritional recovering (group M2). Control pups (C1 and C2 groups) received ad libitum after weaning the same diets as their mothers. Rats of group M2 were nutritionally recovered by receiving the control diet from post-natal day 42 until adulthood. Aldehyde-fixed sections (200-microm thick) through area 17 were processed for NADPH-diaphorase histochemistry following the malic enzyme indirect method. The features of NADPH-diaphorase-containing neurons of area 17 of malnourished young (M1) and adult (M2) rats were analyzed quantitatively in comparison to the matched groups C1 and C2. Permanent changes, represented by increase in the density and dendritic field areas of NADPH-diaphorase-positive cells, and transitory ones, represented by decreased values of soma areas, were observed in area 17 of the M1 and M2 cases. However, some other features, such as dendritic branch angle and number of dendrites per cell in the gray matter, remained unchanged after malnutrition. Thus, the findings indicate a possible relationship between early malnutrition and alterations in nitric oxide synthase-containing cells in the visual cortex. Physiological implications of these data may be related to synaptic plasticity and refinement of developmental brain circuits. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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