| Autor: |
Dedov VN; Department of Pharmacy, School of Biological Sciences, University of Sydney, NSW, Australia. vadimd@pharm.usyd.edu.au, Dedova IV, Armati PJ |
| Jazyk: |
angličtina |
| Zdroj: |
IUBMB life [IUBMB Life] 2000 Jun; Vol. 49 (6), pp. 549-52. |
| DOI: |
10.1080/15216540050167115 |
| Abstrakt: |
The cellular mechanisms involved in axonogenesis are still unclear. In the present work we found that formation of neurites in cultured neonatal dorsal root ganglion neurons co-incided with the redistribution of highly charged mitochondria. Radially distributed in subplasmalemmal space 3 h after plating, highly charged mitochondria formed clusters in the hillocks of predominant neurites during the next 2448 h and then redistributed into the axons. These results provide evidence that accumulation of a critical mass of charged mitochondria at the site of the future axonal hillock may represent the slow initiation stage of axonogenesis, followed by a fast growth phase. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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