| Autor: |
Greeley GH Jr, Allen MB Jr, Mahesh VB |
| Jazyk: |
angličtina |
| Zdroj: |
Neuroendocrinology [Neuroendocrinology] 1975; Vol. 18 (3), pp. 233-41. |
| DOI: |
10.1159/000122402 |
| Abstrakt: |
The objective of this study was to determine the influence of estradiol-17beta and/or progesterone on gonadotropon secretion at the level of the pituitary. Female rats in which the hypothalamo-hypophyseal connections had been permanently interrupted after castration served as the experimental model in which the effect of estradiol and/or progesterone on LH-RH-induced gonadotropin release was examined. In out experimental animals, LH secretion was readily activated by LH-RH administration. LH release was greatly augmented by the prior administration of estradiol benzoate (1 mug/kg b.w./day). Progesterone (5 mg/day) in the absence of estradiol did not modify the 10-min responese to LH-RH but reduced the enhancement of LH secretion caused by estradiol pretreatment. Our findings suggest that estradiol potentiated the releasing effect of LH-RH at the level of the gonadotroph, whereas progesterone interfered with the potentiation effect. Plasma levels of FSH were not significantly elevated above the basal value by the administration of LH-RH alone, or in combination with estradiol and/or progesterone. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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