| Autor: |
Banks BJ; Pfizer Central Research, Sandwich, Kent, UK. bernard_banks@sandwich.pfizer.com, Bishop BF, Evans NA, Gibson SP, Goudie AC, Gration KA, Pacey MS, Perry DA, Witty MJ |
| Jazyk: |
angličtina |
| Zdroj: |
Bioorganic & medicinal chemistry [Bioorg Med Chem] 2000 Aug; Vol. 8 (8), pp. 2017-25. |
| DOI: |
10.1016/s0968-0896(00)00120-6 |
| Abstrakt: |
Evaluation of a wide range of avermectin derivatives for flea activity in an in vitro feeding screen using the cat flea, Ctenocephalides felis, revealed a narrow structure-activity relationship (SAR) with activity surprisingly associated with monosaccharides and especially their C-5-oximes. We discovered commercially exploitable flea activity in a single compound, selamectin 33, which also possessed the necessary antiparasitic spectrum and margin of safety for development as a broad-spectrum companion animal endectocide. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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