| Autor: |
Irwin SA; Neuroscience and Medical Scholars Programs, The Beckman Institute, University of Illinois, Urbana, 61801, USA., Swain RA, Christmon CA, Chakravarti A, Weiler IJ, Greenough WT |
| Jazyk: |
angličtina |
| Zdroj: |
Neurobiology of learning and memory [Neurobiol Learn Mem] 2000 Jul; Vol. 74 (1), pp. 87-93. |
| Abstrakt: |
The Fragile-X mental retardation protein, the protein absent in Fragile-X syndrome, is synthesized near synapses upon neurotransmitter activation. Humans and mice lacking this protein exhibit abnormal dendritic spine lengths and numbers. Here we investigated Fragile-X protein levels in animals exposed to behavioral paradigms that induce neuronal morphological change. Fragile-X protein immunoreactivity was examined in visual cortices of rats reared in a complex environment for 10 or 20 days, motor cortices of rats trained on motor-skill tasks for 3 or 7 days, and either visual or motor cortices of inactive controls. Rats exposed to a complex environment for 20 days or trained for 7 days on motor-skill tasks exhibited increased Fragile-X protein immunoreactivity in visual or motor cortices, respectively. These results provide the first evidence for a behaviorally induced alteration of Fragile-X protein expression and are compatible with previous findings suggesting synaptic regulation of its expression. These results also strengthen the association of Fragile-X mental retardation protein expression with the alteration of synaptic structure. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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