Antiphospholipid syndrome and perioperative hemostatic management of cardiac valvular surgery.

Autor: Hogan WJ; Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, Minn 55905, USA., McBane RD, Santrach PJ, Plumhoff EA, Oliver WC Jr, Schaff HV, Rodeheffer RJ, Edwards WD, Duffy J, Nichols WL
Jazyk: angličtina
Zdroj: Mayo Clinic proceedings [Mayo Clin Proc] 2000 Sep; Vol. 75 (9), pp. 971-6.
DOI: 10.4065/75.9.971
Abstrakt: Hemostatic aspects of antiphospholipid syndrome (APS) present unique challenges to clinicians and laboratory personnel alike, particularly in the perioperative period. These challenges are especially evident in patients requiring cardiac valve replacement surgery. However, the literature outlining the optimal approach in such patients is limited. We present the case of a 25-year-old woman with severe aortic regurgitation as a result of APS with particular reference to the precautions necessary during perioperative care. Particularly important are the prevention of thrombotic or hemorrhagic complications, management of associated thrombocytopenia, and laboratory methods of perioperative anticoagulation monitoring in the setting of prolonged clotting times.
Databáze: MEDLINE