| Autor: |
Nonaka K; Lead Discovery Research Laboratories, Sankyo Co., Ltd., Iwaki-shi, Fukushima, Japan., Tsukiyama T, Okamoto Y, Sato K, Kumasaka C, Yammoto T, Maruyama F, Yoshikawa H |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of antibiotics [J Antibiot (Tokyo)] 2000 Jul; Vol. 53 (7), pp. 694-704. |
| DOI: |
10.7164/antibiotics.53.694 |
| Abstrakt: |
Twelve new milbemycins have been isolated and characterized from some strains derived from Streptomyces hygroscopicus subsp. aureolacrimosus SANK 60286 and SANK 60526. The metabolites 1 approximately 4 and 9 approximately 11 were produced by strain RM28D-688 SANK 60797 as minor products. The metabolites 5 approximaetly 8 were obtained from a broth of strain 57-338 SANK 61796. Strain MK-1391 SANK 62896 was used for the production of metabolite 12. The new metabolites, eight alpha-class and four beta-class compounds, have new structural features. For example, milbemycins alpha26 and alpha27, have the 26-hydroxy moiety, and other derivatives (milbemycins alpha20 approximately 23) have different side chains at the C-26 position from those of milbemycins alpha11 and alpha14. In addition, 5-hydroxylmilbemycin beta7 (beta12), involved in the major biosynthetic pathway of 25-methyl and 25-ethyl milbemycins, was discovered. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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