| Autor: |
Cartmell J; Neuroscience Research, Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Mail Drop 0510, Indianapolis, IN 46285, USA., Monn JA, Schoepp DD |
| Jazyk: |
angličtina |
| Zdroj: |
European journal of pharmacology [Eur J Pharmacol] 2000 Jul 21; Vol. 400 (2-3), pp. 221-4. |
| DOI: |
10.1016/s0014-2999(00)00423-4 |
| Abstrakt: |
We have previously reported that the specific group II metabotropic glutamate receptor agonist LY379268 inhibited phencyclidine (PCP)-induced motor activations in rats, but had mixed effects on behaviors produced by amphetamine. Here, LY379268 (1 mg/kg subcutaneous (s.c.)) attenuated amphetamine-induced ambulations and rearing but did not alter amphetamine-evoked fine motor movements. Consistent with a mechanism involving mGlu(2/3) receptors, the inhibitory actions of LY379268 on ambulations and rearing were reversed by LY341495, a mGlu(2/3) receptor antagonist. These data further suggest antipsychotic actions of mGlu(2/3) receptor agonists with a low propensity for extra-pyramidal side effects. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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