[The 1st results of the combined therapy of recurrent and refractory forms of lymphogranulomatosis (polychemotherapy, radiation therapy and the removal of the residual mediastinal formation)].

Autor:	Stroiakovskiĭ DL, Pivnik AV, Shavlokhov VS, Sotnikov VM, Moiseeva TN, Rasstrigin NA, Margolin OV, Efimov IV, Dzhumabaeva BT, Kaplanskaia IB, Roshchina LS
Jazyk:	ruština
Zdroj:	Terapevticheskii arkhiv [Ter Arkh] 2000; Vol. 72 (7), pp. 42-8.
Abstrakt:	Aim: To achieve a maximal complete remission rate in patients with recurrent and refractory Hodgkin's disease. To find out a group of patients in whom surgical removal of the residual mediastinal mass would be most effective. Material and Methods: 46 patients with Hodgkin's disease received Dexa-BEAM chemotherapy followed by radiotherapy. Surgical removal of the residual mediastinal mass was made in 12 patients. Results: Second-line Dexa-BEAM therapy produced a 50% complete remission rate. Overall survival was 45.5%, the disease-free survival--43.5%. Removed mediastinal masses were indicative of Hodgkin's disease in 7 cases and fibrosis in 4 cases. Conclusion: Dexa-BEAM is an effective program in the treatment of recurrent and refractory Hodgkin's disease. Surgical removal of the residual mediastinal mass with radiotherapy and high-dose chemotherapy improves prognosis in very unfavorable, primary progressive form of Hodgkin's disease.
Databáze:	MEDLINE
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