[The induction of the antitumor activity of T-lymphocytes by antigen-presenting cells obtained from the blast cells of patients with acute leukemias].
| Autor: | Savchenko VG, Sadovnikova EIu, Parovichnikova EN, Mendeleeva LP, Demidova IA, Sokolov AN, Isaev VG |
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| Jazyk: | ruština |
| Zdroj: | Terapevticheskii arkhiv [Ter Arkh] 2000; Vol. 72 (7), pp. 14-21. |
| Abstrakt: | Aim: To produce antigen-presenting cells (APC) from tumor cells of patients with acute leukemia and to induce autologous cytotoxic tumor-specific T-lymphocytes in vivo and in vitro. Material and Methods: Culture examinations, flow cytofluorometry were made in 3 patients with acute myeloid leukemia (AML) and 1 patient with acute lymphoblastic leukemia (ALL). Results: Culturing of blast cells in the presence of growth factors produced APC in 4 patients with acute leukemia. The use of fibronectin layer with added collagen proved most effective for the above production. In culture, APC induced autologous tumor-specific T-lymphocytes which selectively lysed tumor cells. Pilot clinical trial was made of dendritic cells suspension in a patient with resistant AML. Conclusion: A new perspective immunotherapy of acute leukemia is proposed. |
| Databáze: | MEDLINE |
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