| Autor: |
Filatova LV; N. N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg., Gershanovich ML, Ketlinskiĭ SA, Simbirtsev AS |
| Jazyk: |
ruština |
| Zdroj: |
Voprosy onkologii [Vopr Onkol] 2000; Vol. 46 (3), pp. 278-84. |
| Abstrakt: |
The investigation was concerned with the leuko-stimulating effect of interleukin-1 beta injected subcutaneously (4.6 +/- 0.3 ng/kg body), daily, for 10 days, to treat toxic leukopenia and neutropenia stage III in cancer patients. Complete recovery of leukocyte levels and granulocytic count (during an average of 9 +/- 1 days) was registered within a period similar to that of intravenous dropwise injection of a single dose of 10-20 ng/kg body. Distinct protective effect on leukopoiesis was achieved following subcutaneous injection of II-1 beta (4.3 +/- 0.2 ng/kg body) in patients with basic leukopenia stage II and neutropenia stage I carried out in conjunction with combination chemotherapy. Due to side effect cytostatic drug administration could be continued. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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