Phylogenetic signals from point mutations and polymorphic Alu insertions.

Autor: York DS; Biology Department, Hillsdale College, MI 49242, USA., Blum VM, Low JA, Rowold DJ, Puzyrev V, Saliukov V, Odinokova O, Herrera RJ
Jazyk: angličtina
Zdroj: Genetica [Genetica] 1999; Vol. 107 (1-3), pp. 163-70.
Abstrakt: Allelic frequency data derived from five polymorphic Alu insertion loci and five point mutation polymorphic loci were compared to determine their ability to infer phylogenetic relationships among human populations. While point mutation polymorphisms inferred a monophyletic Caucasian clade that is corroborated by other studies, these data failed to support the generally accepted monophyly of Orientals with native Americans. In addition, there is less statistical bootstrap support for the maximum-likelihood tree derived from the point mutation polymorphisms as compared to those generated from either the Alu insertion data or the combined Alu insertion + point mutation data. The Alu data and the combined Alu insertion + point mutation data inferred a monophyletic relationship among the Oriental and native American populations. The Alu insertion data and the combined Alu insertion + point mutation data also displayed two separate, well defined, tight clusters of the Caucasian and the Oriental + native American populations which was not inferred from the point mutation data. These findings indicate greater phylogenetic information contained in Alu insertion frequencies than in allelic frequencies derived from point-mutations.
Databáze: MEDLINE
Externí odkaz: